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Bouchra Rezzouk,1 Tarik Bouattar,2,3 Bouchra Belkadi,1 Rachid Razine,4 Rabia Bayahia,2,3 Naima Ouzeddoun,2,3 Loubna Benamar,2,3 Hakima Rhou,5 Najat Bouihat,6 Azeddine Ibrahimi,3,7 Myriam Seffar,3,6 Hakima Kabbaj3,6
1Laboratory of Microbiology and Molecular Biology, College of Science, College Mohammed V, Rabat, Morocco; 2Division of Nephrology, Dialysis, Renal Transplantation, Ibn Sina College Hospital Middle, Rabat, Morocco; 3College of Medication and Pharmacy, Mohammed V College, Rabat, Morocco; 4Laboratory of Social Medication, Epidemiology and Medical Analysis, College of Medication and Pharmacy, Mohammed V College, Rabat, Morocco; 5Division of Nephrology, Dialysis, Renal Transplantation, Sheikh Zaid Worldwide College Hospital, Rabat, Morocco; 6Central Laboratory of Virology, Hospital of Specialties, Ibn Sina College Hospital Middle, Rabat, Morocco; 7Biotech Laboratory (Med Biotech), College of Medication and Pharmacy, Mohammed V College, Rabat, Morocco
Correspondence: Bouchra Rezzouk 7, Avenue Madagascar, Rabat, Morocco
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Objective: Regardless of the usage of antiviral prophylaxis with valacyclovir, cytomegalovirus an infection (CMV) can nonetheless happen in seropositive kidney transplant recipients. On this research, we aimed to evaluate the incidence of CMV DNAemia and its danger components in Moroccan transplant recipients.
Sufferers and Strategies: Sixty kidney recipients with optimistic cytomegalovirus serostatus, receiving post-transplant prophylaxis had been enrolled between 2013 and 2017. In complete, 455 plasma samples had been collected and examined for CMV DNAemia utilizing PCR-based Abbott RealTime assays.
Outcomes: The incidence of CMV an infection in seropositive sufferers was 63%. In sufferers with quantifiable DNAemia, the period of CMV an infection was considerably shorter than in these with detectable DNAemia (141.5 ± 96.9 vs 294.1 ± 112.6 days, P < 0.001). Throughout prophylactic therapy, 14 of 30 sufferers (47.0%) skilled energetic replication with quantifiable DNAemia, whereas none of eight sufferers with detectable DNAemia did (P = 0.017). Sufferers with symptomatic DNAemia had been considerably youthful than these with out signs (28.8 ± 5.12 vs 38.1 ± 12.34 years, P = 0.007). The height viral hundreds had been considerably related to viral illness (odds ratio: 3.39, 95% confidence interval: 1.21– 9.53, P = 0.02). The period of DNAemia (21.2 vs 13.Four days, P = 0.028) was considerably longer in symptomatic sufferers. Considerably increased charges of acute rejection had been solely noticed in recipients with illness (4/8, 50% vs 0/22, 0%, P = 0.003).
Conclusion: Sufferers with high-level DNAemia had been at an elevated danger of development to illness and acute rejection. Monitoring the viral load in the course of the first 12 months post-transplantation is crucial, to help present preventive methods.
Key phrases: cytomegalovirus, DNAemia, kidney transplant, illness, acute rejection
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