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FDA approves new indication for Lokelma

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By creator to www.healio.com

Mene Pangalos

The FDA has up to date the dosing routine for Lokelma to permit therapy of hyperkalemia in sufferers with end-stage kidney illness who’re on persistent hemodialysis.

Lokelma (sodium zirconium cyclosilicate) is a potassium binder made by AstraZeneca indicated for the therapy of hyperkalemia in grownup sufferers. Beforehand, dosing was not established for sufferers with ESKD on persistent hemodialysis.

“Greater than 500,000 sufferers within the U.S. live with dialysis-dependent end-stage renal illness and may very well be in danger for dangerously excessive ranges of potassium,” Mene Pangalos, govt vice chairman of biopharmaceuticals analysis and improvement for AstraZeneca, stated in a press launch. “With this FDA accepted replace, the Lokelma label now contains necessary dosing steering for treating hyperkalemia in sufferers on hemodialysis.”

The corporate stated that approval was based mostly on outcomes from the double-blind, placebo-controlled part 3b Dialize trial that evaluated the efficacy of Lokelma in 196 persistent hemodialysis sufferers with persistent pre-dialysis hyperkalemia (imply baseline potassium 5.eight mEq/L).

Outcomes confirmed the Lokelma therapy arm had a considerably higher proportion of responders in contrast with placebo (41.2% vs. 1%), the corporate stated. Moreover, 2.1% of sufferers handled with Lokelma wanted rescue remedy to cut back serum potassium for extreme hyperkalemia throughout the therapy interval in contrast with 5.1% of the placebo arm.

The protection profile of Lokelma was in step with that seen in earlier trials.

The corporate stated the label replace for Lokelma is the primary in america following its FDA approval in 2018 to deal with adults with hyperkalemia. With the FDA approval, the label replace for sufferers on persistent hemodialysis now features a beginning dose of 5 g as soon as every day on non-dialysis days and a beginning dose of 10 g as soon as every day on nondialysis days in sufferers with serum potassium higher than 6.5 mmol/L.

Lokelma is accepted in america, European Union, Canada, Hong Kong, China, Russia and Japan, the corporate stated.

— to www.healio.com

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