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Washington, DC—The therapy of alternative for sufferers with end-stage renal illness is kidney transplantation, and dwelling donor kidney transplantation is the optimum mannequin. There are few information obtainable on the predictive worth of renal quantity measurement in predicting long-term donor and recipient graft consequence.
Chaudhry Adeel Ebad, MBBS, MRCPI, and colleagues at Beaumont Hospital, Dublin, Eire, carried out a retrospective cohort examine of dwelling donor transplantation carried out from 2010 to 2017. The researchers utilized information from the Nationwide Kidney Transplant Service of Eire. TeraRecon USA was used to measure renal quantity bilaterally in dwelling kidney donors. Outcomes of the examine had been reported throughout a poster session at Kidney Week 2019 in a poster titled Donor Kidney Renal Quantity Predicts Recipient and Donor Graft Perform at 1 Yr.
Low estimated glomerular filtration fee (eGFR), outlined as <60 mL/min/1.73 m2, in recipients and donors was utilized in logistic regression fashions with donor quantity stratified into tertiles. The fashions included donor and recipient traits as potential confounding variables.
Throughout the examine interval, there have been 166 dwelling donor kidneys transplanted. Imply donor age was 44.eight years, imply physique mass index was 25.5 kg/m2, and imply kidney quantity was 152.7 mls. The tertiles of donor kidney quantity had been: (1) 89.2 to 135 mls; (2) 136 to 164 mls; and (3) 165 to 240 mls. At 1 yr post-transplant, median donor estimated glomerular filtration fee (eGFR) was 63.Three mL/min/1.73 m2. Imply age of recipients of dwelling donor kidneys was 43.5 years, and imply recipient eGFR at 1 yr post-transplant was 58.Three mL/min/1.73 m2.
There was a slight correlation between donor kidney quantity and donor eGFR at 1 yr post-transplant; utilizing the kidney quantity tertile classes, the correlation was marginally nonsignificant in logistic regression (odds ratio [OR], 0.65; 95% confidence interval [CI], 0,40-1.04; P=.075). There was a correlation between donor kidney quantity and recipient eGFR at 1 yr post-transplant; the correlation remained vital in multivariable logistic regression (OR, 0.48; 95% CI, 0.26-0.90; P=.021).
In conclusion, the researchers stated, “Donor kidney quantity predicts recipient graft perform 1 yr post-transplant however is much less conclusive for donor kidney perform. Cognizance of donor renal quantity could assist optimize potential kidney donor choice.”
Supply: Ebad CA, Chevarria JL, Sexton DJ, et al. Donor kidney renal quantity predicts recipient and donor graft perform at 1 yr. Summary of a poster offered throughout the American Society of Nephrology Kidney Week 2019 (Summary TH-PO1130), November 7, 2019, Washington, DC.
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