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Sufferers being evaluated for the efficacy and security of cell remedy to ascertain immune tolerance that enables for full withdrawal of immunosuppressive medication in HLA-matched dwelling donor kidney transplant recipients
SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–
Medeor Therapeutics, Inc., a clinical-stage firm devoted to the event and commercialization of immunotherapies for transplantation, at this time introduced that interim outcomes of its Section three examine medical trial for MDR-101 cell remedy will likely be offered as a Speedy Fireplace Oral Presentation by lead Principal Investigator Dr. Dixon Kaufman of the College of Wisconsin on the American Transplant Congress (ATC) on June 7, 2021.
Medeor’s Section three tolerance examine is a randomized, multi-center examine evaluating the institution of purposeful immune tolerance in MDR-101 recipients of HLA-matched dwelling donor kidney transplants. That is the primary randomized, multi-center pivotal examine particularly designed to eradicate using immunosuppressive anti-rejection medication following transplant.
At present, sufferers who obtain a kidney transplant are dependent upon a lifelong routine of immunosuppressive medication – usually as much as 25 capsules a day – which can be related to a litany of unwanted side effects and toxicities, and restricted efficacy which finally impression graft and affected person survival, such that 30% to 50% of all kidney transplants fail by 10 years. MDR-101 is a single-dose mobile remedy derived from a dwelling kidney donor’s blood. The remedy is designed to ascertain blended chimerism – the co-existence of each recipient-derived and donor-derived blood and immune cells – to permit HLA-matched dwelling donor kidney transplant recipients to discontinue immunosuppressive drug use whereas preserving long-term graft operate and survival.
Particulars of the oral presentation are as follows:
Presentation Title: MDR-101-MLK-MERCURY Kidney Transplant Tolerance Examine Replace
Session Identify: Biomarkers, Immune Evaluation and Scientific Outcomes – III
Summary quantity: 223
Presentation Time: 5:00 pm – 5:05 pm ET
Medeor Therapeutics can also be internet hosting a digital symposium, “Reprogramming the Immune System to Protect Kidney Operate Submit Transplant” on Wednesday, June 17, 2021 at 7–eight pm ET to debate the most recent advances in organ transplant cell remedy to induce donor-specific immune tolerance and keep away from transplant kidney rejection. The symposium will embody a KOL roundtable that includes:
- Stephan Busque, M.D., Stanford College Medical Heart
- Dixon Kaufman, M.D., Ph.D., College of Wisconsin Faculty of Drugs and Public Well being
- Sanjeev Akkina, M.D., Loyola College Medical Heart
- Daniel Brennan, M.D., Medeor Therapeutics (moderator)
As well as, Medeor Therapeutics Chief Medical Officer Dr. Daniel Brennan will present an organization overview and replace on future plans.
To register for the symposium, please go to https://www.eventbrite.com/e/redefining-organ-transplants-virtual-symposium-june-17-2021-tickets-155809822373.
MDR-101 is a single dose mobile remedy manufactured from a dwelling kidney donor’s blood and peripheral stem cells. MDR-101 is meant to induce donor-specific immune tolerance with a view to avert transplant kidney rejection and thereby protect transplant kidney operate and survival with out the cumulative and critical unwanted side effects related to immunosuppressive medication. Medeor’s Section three trial is supported partly by a grant from the California Institute for Regenerative Medicine. For extra data on Medeor’s Section three trial, please go to https://clinicaltrials.gov.
About Medeor Therapeutics, Inc.
Medeor Therapeutics is working to enhance the lives of transplant sufferers by eliminating or minimizing the necessity for a life-long routine of immunosuppressive medicines and their potential life-threatening unwanted side effects. Medeor’s Section three medical examine is demonstrating the numerous alternatives of this one-time remedy. For extra data, go to www.medeortx.com.
Direct: +1 781 235 3060
Supply: Medeor Therapeutics, Inc.