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Hepatitis C treatments could expand organ donor pool, study suggests

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Hepatitis C treatments could expand organ donor pool, study suggests

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Hepatitis C treatments could expand organ donor pool, study suggests
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By writer to www.modernhealthcare.com

Because the Trump administration eyes easing organ transplant restrictions, new analysis reveals advances in hepatitis C remedies might create a complete new group of donors.

When evaluating coronary heart transplant sufferers’ survival charges, researchers discovered no vital variations between sufferers who acquired organs from hepatitis C-positive donors and uninfected donors. The research printed Wednesday in JAMA Cardiology reviewed 80 coronary heart transplant sufferers’ outcomes.

Utilizing hepatitis C-infected hearts in uninfected recipients might broaden the donor pool, significantly for rural areas the place accessible donors are restricted and hepatitis C charges have risen as a result of opioid epidemic, in accordance with lead research writer Dr. Kelly Schlendorf, medical director of the grownup coronary heart transplant program at Vanderbilt College Medical Heart in Nashville.

Tennessee had the 15th-highest fee of drug overdose deaths amongst states in 2017 at 26.6 for each 100,000 people, in accordance with the latest figures from the Centers for Disease Control and Prevention.

“These donors provide a really viable technique of increasing the donor pool that appears to be secure,” Schlendorf mentioned. “Primarily based on the place (transplant) facilities are positioned all through the nation, some facilities might profit extra from this technique than others.”

Vanderbilt’s donor pool has elevated considerably because it began accepting hepatitis C-positive donors in September 2016, she mentioned. They now account for 37% of all grownup coronary heart transplants on the well being system. Vanderbilt performs twice as many coronary heart transplants because the change, leaping from 130 between 2013 and 2015 to 260 between 2016 and 2018.

Utilizing hepatitis C-infected hearts considerably lowered wait occasions for recipients, in accordance with the research. Median wait occasions vary from 70 to 535 days relying on a affected person’s blood sort, the latest information from HHS’ Organ Procurement and Transplantation Network reveals. VUMC sufferers who consented to receiving a coronary heart from hepatitis C-positive donors had a median wait time of 4 days.

In 2018, greater than 950 sufferers died whereas ready for a transplant or had been faraway from the wait listing as a result of they turned too ailing.

Previously, clinicians opposed utilizing hepatitis C-infected organs for transplant as a result of the illness’s therapy routine had harsh unwanted side effects and a treatment fee of about 50%. These transplant recipients typically had poorer outcomes, together with increased charges of organ rejection.

However that mindset began to alter in 2011 when direct-acting antiviral drugs got here available on the market, which elevated the treatment fee to over 95% and included fewer and milder unwanted side effects, in accordance with Dr. Maria Rosa Costanzo, a volunteer professional for the American Coronary heart Affiliation and medical director of coronary heart failure analysis Advocate Aurora Well being’s Coronary heart Institute.

Just one coronary heart transplant in 2015 concerned a hepatitis C-positive donor, in contrast with 154 as of September 2019, in accordance with the latest OPTN figures.

“There have been a whole lot of beliefs about acceptable versus unacceptable donors,” Costanzo mentioned. “I believe we’re in an period the place a whole lot of the previous beliefs are turning out to not trigger a worse end result in recipients.”

The research was printed a day after the Trump administration proposed changes to the organ transplantation procurement course of. The modifications embrace permitting residing donors to be reimbursed for misplaced wages and hospitalization bills and creating more durable reporting requirements for procurement organizations. The administration hopes the modifications will result in extra accessible donors.

— to www.modernhealthcare.com

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