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BK virus-associated nephropathy (BKVAN) is related to allograft dysfunction and graft failure in kidney transplant recipients. Discount of immunosuppression is the gold commonplace of remedy for BKVAN, presumably rising the chance for acute rejection.
Researchers in South Korea, led by Ji Gained Min, MD, utilized information from the Korean Organ Transplantation Registry, a nationwide organ transplantation database, to check graft perform and allograft survival in sufferers with BKVAN with or with out biopsy-proven acute rejection (BPAR). Outcomes of the evaluation had been reported throughout a digital poster session on the 28th Worldwide Congress of the Transplantation Society in a poster titled Differential Influence of Allograft Rejection on Kidney Transplant Sufferers with BKV An infection.
Of the 5403 kidney transplant recipients who underwent transplantation between 2014 and June 2019, 97 had been identified with BKVAN. Of these, 27% (n=26) developed BPAR inside 5 months of the analysis of BKVAN; 71 sufferers didn’t develop BPAR. At baseline, each teams (with and with out BPAR) had related traits, immunosuppression remedy, and remedy strategies for BKVAN.
Within the BPAR group, there was a major lower in allograft perform in contrast with the group with out BPAR at each the 1 12 months and a pair of 12 months follow-up interval (BPAR creatinine [Cr] 2.5 vs no BPAR Cr, 1.9; P=.044 and BPAR Cr 3.eight vs no BPAR Cr 2.2; P=.015, respectively). Allograft survival charges had been decrease within the BPAR group than within the no-BPAR group; nonetheless the distinction didn’t attain statistical significance (P=.474).
In multivariate Cox regression evaluation, discontinuation of mycophenolate mofetil (MMF) was seen as a major danger issue for rejection in sufferers with BKVAN (hazard ratio, 4.000; 95% confidence interval, 1.014-15.775; P=.048).
In conclusion, the researchers mentioned, “Acute rejection with BKVAN is related to poorer allograft perform and survival. Additionally, discontinuation of MMF as remedy for BKVAN will increase danger for acute rejection.”
Supply: Min JW, Jun KW, Park JB, et al. Differential impression of allograft rejection on kidney transplant sufferers with BVK an infection. Summary of a poster introduced on the digital 28th Worldwide Congress of the Transplantation Society (Summary P-11.55), September 13-16, 2020.
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