By writer to www.renalandurologynews.com
Kidney transplant recipients who obtain a purple blood cell (RBC) transfusion are at elevated threat for venous thromboembolism (VTE), information offered throughout the American Society of Nephrology’s Kidney Week 2021 counsel.
“Our research presents novel findings highlighting one more reason to restrict the usage of blood transfusions in kidney transplant recipients,” David Massicotte-Azarniouch, MD, of the College of Ottawa in Ontario, Canada, and colleagues concluded in a poster presentation.
The research, which was retrospective, included 1258 recipients of kidney transplants at The Ottawa Hospital from 2002 to 2018. Of those, 468 (37%) acquired a complete of 2373 RBC transfusions after transplantation. Throughout follow-up, VTE developed in 79 sufferers (6.3%), deep venous thrombosis (DVT) developed in 72 (5.7%), and pulmonary embolism (PE) occurred in 22 (1.8%).
In contrast with no RBC transfusion, receipt of any RBC transfusion was considerably related to roughly a 2.8-fold elevated threat for VTE, 3.3-fold elevated threat for DVT, and a pair of.4-fold elevated threat for PE, after adjusting for age, intercourse, transplant sort, presence of diabetes and heart problems, and kind of upkeep remedy, Dr Massicotte-Azarniouch and colleagues reported.
The dangers diversified by variety of RBC items acquired. In contrast with no transfusion, receipt of two, 3-5, and greater than 5 RBC items was considerably related to roughly 2.5-, 2.7-, and 5.8-fold elevated dangers for VTE occasions, respectively, and a pair of.9-, 3.3-, and seven.0-fold elevated dangers for DVT, respectively. Receipt of greater than 5 RBC items was considerably related to a 7.7-fold elevated threat for PE.
“Receipt of blood transfusion in kidney transplant recipients is related to a step-wise elevated threat for VTE, DVT and PE because the variety of transfusions will increase,” the investigators said.
Massicotte-Azarniouch, Sood MM, Fergusson DA, Chasse M, Tinmouth A, Knoll G. Blood transfusion and venous thromboembolism in kidney transplant patients. Offered at: Kidney Week 2021, November 2-7, 2021. Poster PO2119.