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Mahtabalsadat Mirjalili,1 Mojtaba Shafiekhani,1,2 Afsaneh Vazin1
1Division of Scientific Pharmacy, School of Pharmacy, Shiraz College of Medical Sciences, Shiraz, Iran; 2Shiraz Organ Transplant Heart, Abu-Ali Sina Hospital, Shiraz College of Medical Sciences, Shiraz, Iran
Correspondence: Mojtaba Shafiekhani
Shiraz Organ Transplant Heart, Abu-Ali Sina Hospital, Shiraz College of Medical Sciences, Shiraz, Iran
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Division of Scientific Pharmacy, School of Pharmacy, Shiraz College of Medical Sciences, Shiraz, Iran
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Summary: The 2019 novel coronavirus illness (COVID-19) was first detected in Wuhan, Hubei Province, China, in late 2019. Since then, COVID-19 has unfold to greater than 200 nations on the planet, and a world pandemic has been declared by the World Well being Group (WHO). At current, no vaccines or therapeutic regimens with confirmed efficacy can be found for the administration of COVID-19. Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, comparable to tocilizumab, have been really helpful as potential remedy choices in COVID-19. Transplant sufferers receiving immunosuppressant medicines are on the highest threat of extreme sickness from COVID-19. On the similar time, with regard to receiving polypharmacy and immunosuppressants, remedy choices must be chosen with extra consideration on this inhabitants. Contemplating drug–drug interactions and adversarial results of medicines used for the remedy of COVID-19, comparable to QT prolongation, the dose discount of some immunosuppressants or avoidance is really helpful in transplant recipients with COVID-19. Thus, this narrative overview describes clinically vital concerns in regards to the remedy of COVID-19 and immunosuppressive regimens concerning modifications, unwanted side effects, and interactions in grownup kidney or liver allograft recipients.
Key phrases: SARS-CoV-2, COVID-19, liver transplant, kidney transplant, immunosuppressive, transplantation
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