Simultaneous Pancreas/Kidney Transplant versus Kidney Transplantation Alone

Researchers at Tianjin First Central Hospital, Tianjin, China, led by X. Y. Fu, carried out a examine to match renal operate, metabolic profiles, and survival outcomes amongst sufferers with end-stage kidney illness (ESKD) and diabetes mellitus present process simultaneous pancreas kidney transplantation (SPK) with these present process kidney transplantation alone. Outcomes of the examine have been reported throughout a digital session on the 2021 American Transplant Congress. The presentation was titled Superior Metabolic Operate of Kind 2 Diabetes Mellitus Sufferers after Simultaneous Kidney/Pancreas Transplantation in contrast with Kidney Transplantation Alone.
The researchers retrospectively analyzed information on sufferers with ESKD and sort 2 diabetes who underwent SPK (n=85) or kidney transplantation alone (n=71). Information on demographics, perioperative parameters, postoperative blood glucose and lipid profiles, issues, and survival outcomes within the two cohorts have been analyzed. Blended results fashions have been used to match information between the cohorts.
Basically, sufferers within the SPK group have been youthful than these within the kidney transplantation alone group (imply, 49.01 years vs 52.14 years; P=.018); donor age within the SPK group was additionally youthful than within the kidney transplantation alone group (imply, 32.1 years vs 47.14 years; PP=.393), decrease fasting serum glucose degree (PP=.0439), and decrease ldl cholesterol degree (P=.002). The speed of an infection was greater within the SPK cohort than within the kidney transplantation alone cohort (38% vs 22.4%, respectively; P=.003). There have been no important variations between the 2 cohorts in survival outcomes.
In conclusion, the researchers stated, “SPK gives higher renal operate and metabolic outcomes, however has greater charge of an infection than kidney transplantation alone for ESKD-type 2 diabetes mellitus sufferers. The 5-year survival outcomes of recipients and grafts have been comparable between the 2 teams.”
Supply: Fu X Y, YU C, Wang H, et al. Superior metabolic operate of kind 2 diabetes mellitus sufferers after simultaneous kidney/pancreas transplantation in contrast with kidney transplantation alone. Summary of a presentation on the digital 2021 American Transplant Congress (Summary #896), June 5, 2021.