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Transplant Proc. 2020 Dec 16:S0041-1345(20)32904-3. doi: 10.1016/j.transproceed.2020.11.009. On-line forward of print.
BACKGROUND: In liver transplant (LT) recipients with extreme coronavirus illness 2019 (COVID-19), deadly final result has been reported in a considerable subset of sufferers. Whether or not LT recipients are at elevated danger for extreme COVID-19 in contrast with the overall inhabitants is controversial. Right here we report the outcomes of a extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in a big LT recipient cohort.
METHODS: A complete of 219 LT recipients have been enrolled between Might 5, 2020, and August 6, 2020, on the College Hospital Heidelberg. Serum blood samples have been collected and examined for anti-SARS-CoV-2 IgG. SARS-CoV-2 RNA was detected in nasopharyngeal swabs utilizing reverse transcription-polymerase chain response assays.
RESULTS: Considering identified danger elements of arterial hypertension, weight problems, diabetes, or leukopenia, LT recipients a priori represented a high-risk cohort for extreme COVID-19 with 101 of 219 (46.1%) presenting with greater than 2 danger elements for extreme COVID-19. Out of 219 LT recipients, 8 (3.7%) both had a optimistic check end result for nasopharyngeal SARS-CoV-2 RNA or anti-SARS-CoV-2 serum IgG. 5 of eight (62.5%) didn’t present any scientific indicators of an infection, three of eight (37.5%) had self-limited illness, and none required hospitalization for COVID-19. Two of eight (25%) had identified publicity to contaminated well being care workers because the possible supply of an infection.
CONCLUSIONS: In abstract, LT recipients confirmed a SARS-CoV-2 seroconversion charge much like that of the overall inhabitants with a considerable share of unrecognized infections.
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